Physical fitness in core strengthening training in university students practicing aerobic gymnastics / Aptidão física no treino de fortalecimento do core em universitárias praticantes de ginástica aeróbica / Aptitud física en el entrenamiento de fortalecimiento del core en estudiantes universitarias que practican gimnasia aeróbica

ABSTRACT Introduction Aerobic gymnastics is an emerging sport. It develops mainly the aerobic body metabolism improving the cardiopulmonary function of the practitioner. Objective To analyze the influence of core strength training on the physical fitness of university athletes who practice aerobic gymnastics. Methods Using mathematical statistics, we studied the influence of aerobic exercise on the physical fitness of female college athletes. The fitness index test of female college aerobics athletes was performed with Excel 2007, and the obtained results were discussed. Results College female students showed significant improvement in somatization, interpersonal sensitivity, anxiety, and other four factors after aerobic gymnastics exercise (P<0.05). After the practice period, female college students improved orthostatic performance, long jump, stretching in sitting forward position, 1 minute sitting, running four times round trip for 10 meters, and 800 meters. The increase was 11.16cm, 5.02cm, 8.34 times/min, 2.13s, and 9.42s. Conclusion Core training in aerobic gymnastics can strengthen the body, allowing awareness of physical training in college women. Evidence Level II; Therapeutic Studies - Investigating the results.

RESUMO Introdução A ginástica aeróbica é um esporte emergente. Ela desenvolve principalmente o metabolismo aeróbico corporal aprimorando a função cardiopulmonar do praticante. Objetivo Analisar a influência no treino de fortalecimento do core sobre a aptidão física em atletas universitárias praticantes de ginástica aeróbica. Métodos Utilizando estatísticas matemáticas, estuda-se a influência do exercício aeróbico sobre a aptidão física das atletas universitárias. O teste do índice de aptidão física de atletas de aeróbica feminina de faculdades foi executado com Excel 2007 e discutiu-se os resultados obtidos. Resultados As estudantes universitárias apresentaram melhora significativa na somatização, sensibilidade interpessoal, ansiedade, e outros quatro fatores após o exercício de ginastica aeróbica (P<0,05). Após o período de prática, as estudantes universitárias tiveram melhora no desempenho ortostático, salto à distância, no alongamento em posição sentadas para frente, 1 minuto sentadas, corrida 4 vezes de ida e volta por 10 metros, e 800 metros. O aumento foi respectivamente de 11,16cm, 5,02cm, 8,34 vezes/min, 2,13s, e 9,42s. Conclusão O treino do core na ginástica aeróbica pode fortalecer o corpo, permitindo a conscientização do treino físico nas universitárias. Nível de evidência II; Estudos Terapêuticos - Investigação de Resultados.

RESUMEN Introducción La gimnasia aeróbica es un deporte emergente. Desarrolla principalmente el metabolismo corporal aeróbico mejorando la función cardiopulmonar del practicante. Objetivo Analizar la influencia del entrenamiento del core en la aptitud física en atletas universitarias que practican gimnasia aeróbica. Métodos Utilizando la estadística matemática, se estudió la influencia del ejercicio aeróbico en la aptitud física de las atletas universitarias. La prueba del índice de aptitud física de las atletas universitarias de aerobismo se realizó con Excel 2007 y se discutieron los resultados obtenidos. Resultados Las estudiantes universitarias mostraron una mejora significativa en la somatización, la sensibilidad interpersonal, la ansiedad y otros cuatro factores después del ejercicio de gimnasia aeróbica (P<0,05). Después del periodo de práctica, las estudiantes universitarias tuvieron una mejora en el rendimiento ortostático, en el salto de longitud, en el estiramiento en posición sentada hacia delante, en la posición sentada de 1 minuto, en la carrera de 4 vueltas de 10 metros y en los 800 metros. El aumento fue, respectivamente, de 11,16 cm, 5,02 cm, 8,34 veces/min, 2,13 s y 9,42 s. Conclusión El entrenamiento del core en la gimnasia aeróbica puede fortalecer el cuerpo, permitiendo la concienciación del entrenamiento físico en las estudiantes universitarias. Nivel de evidencia II; Estudios terapéuticos - Investigación de resultados.

Long non-coding RNA DLGAP1-AS1 promotes the progression of gastric cancer via miR-515-5p/MARK4 axis

Long non-coding RNA (lncRNA) is an essential regulator of carcinogenesis and cancer progression. In the study, we explored the role of lncRNA DLGAP1-AS1 in gastric cancer (GC). qRT-PCR was carried out to detect DLGAP1-AS1 expression in GC tissues and cell lines. CCK-8 assay, EdU assay, and transwell experiments were employed to detect the malignant biological behaviors of GC cells with DLGAP1-AS1 knockdown or overexpression. Bioinformatics and dual-luciferase report assay were used to confirm the binding relationship between DLGAP1-AS1 and miR-515-5p. MARK4 expression was detected by western blot after DLGAP1-AS1/miR-515-5p was selectively regulated. DLGAP1-AS1 was up-regulated in GC tissues and cell lines, and its high expression was closely associated with larger tumor size, higher TNM stage, and lymph node metastasis. Furthermore, DLGAP1-AS1 overexpression enhanced cell proliferation, migration, and invasion, and miR-515-5p could reverse these effects. DLGAP1-AS1 participated in the regulation of the MARK4 signaling pathway by targeting miR-515-5p. DLGAP1-AS1 promoted GC progression through miR-515-5p/MARK4 signaling pathway.

Abnormal spinal curvature and influencing factors in children and adolescents in Hongkou District, Shanghai / 中国学校卫生

Objective@#To investigate the incidence of abnormal spinal curvature and related factors in primary and secondary school students in the Hongkou District of Shanghai, so as to provide evidence for abnormal spinal curvature prevention and treatment.@*Methods@#Using a stratified cluster random sampling method, 1 884 students of grade 4 to grade 12 from seven schools were investigated via questionnaires for abnormal spinal curvature in Hongkou District.@*Results@#The detectable rate of abnormal spinal curvature was 7.2%, The detectable rate of abnormal spinal curvature increased with increasing age(P<0.01): senior high school (15.7%) > vocational high school (8.1%) > junior high school (3.4%) > primary school(1.8%)(χ 2=91.24, P<0.01). The detectable rate of spinal curvature among female students was 8.6%, which was higher than that among male students(5.9%), and the difference was significant(χ 2=5.27, P<0.05). Multivariate Logistic regression analysis showed that the factors influencing abnormal spinal curvature included phase of studying, nutritional status and time spent engaged in outdoor activities every day(P<0.05).@*Conclusion@#Abnormal spinal curvature is one of the common conditions that endangers the health of children and adolescents. The collaboration of the school, students and parents is required to strengthen screening and prevention.

Profile of renal artery embolization (RAE) for renal trauma: A comparison of data from two major trauma center

ABSTRACT Objective To evaluate usage of renal artery embolization (RAE) for renal injuries and discuss the indications for this treatment. Materials and Methods A retrospective study was performed evaluating the electronic medical records of all patients with renal trauma admitted to two major comprehensive hospitals in Shantou city from January 2006 to December 2015. Results There were 264 and 304 renal traumatic patients admitted to hospital A and B, respectively. LGRT was the reason for presentation in the majority of patients (522, 91.9%). A total of 534 (94.0%) patients were treated conservatively. RAE was performed in 9 patients from 2012 to 2015 at hospital A, including in 6 patients (6/9, 66.7%) with LGRT, and 3 patients (3/9, 33.3%) with HGRT. No patient underwent interventional therapy (RAE) at hospital B during the same period. No significant differences in the operative rate of hospital A were observed between the two time periods (2006-2011 and 2012-2015). The operative rate for LGRT between the two hospitals from 2006 to 2011 and 2012 to 2015 was not significantly different. Hospital A showed a significant decrease in the rate of conservative treatment for patients with LGRT. In the univariate and multivariate analyses, the AAST renal grade both were significantly associated with undergoing RAE. Conclusions LGRT was present in the majority of patients, and most cases of renal trauma could be treated with conservative treatment. RAE was well utilized for the treatment of renal trauma. However, some patients with LGRT were treated with unnecessary interventional therapy.

Identification of key genes involved in nasopharyngeal carcinoma / Identificação dos principais genes envolvidos no carcinoma nasofaríngeo

Abstract Introduction: Nasopharyngeal carcinoma is the most common cancer originating from the nasopharynx. Objective: To study the mechanisms of nasopharyngeal carcinoma, we analyzed GSE12452 microarray data. Methods: GSE12452 was downloaded from the Gene Expression Omnibus database and included 31 nasopharyngeal carcinoma samples and 10 normal nasopharyngeal tissue samples. The differentially expressed genes were screened by ANOVA in the PGS package. Using the BiNGO plugin in Cytoscape and pathway enrichment analysis in the PGS package, functional and pathway enrichment analyses were performed separately to predict potential functions of the differentially expressed genes. Furthermore, Transcription factor-differentially expressed gene pairs were searched, and then the transcription factor-differentially expressed gene regulatory network was visualized using Cytoscape software. Results: A total of 487 genes were screened as differentially expressed genes between the nasopharyngeal carcinoma samples and the normal nasopharyngeal tissue samples. Enrichment analysis indicated that PTGS2 was involved in the regulation of biological process and small cell lung cancer. ZIC2 and OVOL1 may function in nasopharyngeal carcinoma through targeting significantly up-regulated genes (such as PTGS2, FN1, CXCL9 and CXCL10) in the Transcription factor-differentially expressed gene regulatory network (e.g., ZIC2→PTGS2 and OVOL1→CXCL10). Conclusion: PTGS2, FN1, CXCL9, CXCL10, ZIC2 and OVOL1 might play roles in nasopharyngeal carcinoma.

Resumo Introdução: O carcinoma nasofaríngeo é o câncer mais comum originário da nasofaringe. Objetivo: Estudar os mecanismos do câncer de nasofaringe; dados do microarray GSE12452 foram analisados. Método: GSE12452 foi obtido da base de dados Gene Expression Omnibus e inclui 31 amostras de carcinoma nasofaríngeo e 10 amostras de tecido nasofaríngeo normal. Os genes diferencialmente expressos foram analisados por ANOVA no kit PGS. Usando o plugin BiNGO no Cytoscape e análise de enriquecimento da via no kit PGS, análises de enriquecimento funcional e da via foram realizadas separadamente para prever as potenciais funções dos genes diferencialmente expressos. Além disso, os pares Fator de Transcrição - genes diferencialmente expressos foram pesquisados e em seguida a sua rede reguladora foi visualizada usando o programa Cytoscape. Resultados: Um total de 487 genes foram analisados como genes diferencialmente expressos entre as amostras de carcinoma nasofaríngeo e amostras de tecido nasofaríngeo normal. A análise de enriquecimento indicou que PTGS2 estava envolvido na regulação do processo biológico e câncer pulmonar de pequenas células. ZIC2 e OVOL1 podem funcionar no carcinoma nasofaríngeo almejando-se de maneira significativa os genes suprarregulados (como o PTGS2, FN1, CXCL9 e CXCL10) na rede reguladora de fator de transcrição - genes diferencialmente expressos (p.ex., ZIC2→PTGS2 e OVOL1→CXCL10). Conclusão: PTGS2, FN1, CXCL9, CXCL10, ZIC2 e OVOL1 podem desempenhar alguns papéis no carcinoma de nasofaringe.

Research progress on the role of resveratrol in age-related eye diseases / 国际眼科杂志(Guoji Yanke Zazhi)

Age-related eye diseases are a set of ophthalmic diseases caused by aging and irreversible degeneration in the eye.Glaucoma,cataract,and age-related macular degeneration (AMD) are some of the common age-related eye diseases.Inflammation and oxidative stress play important roles in the initiation and progression of these diseases.Resveratrol,a natural plant antitoxin,fights oxidative stress and inflammation by regulating multiple cellular transduction pathways;and it has become a focal point in anti-aging research and has seen significant research progress during recent years.At the present,investigation into the relationship between resveratrol and age-related eye diseases is still in its infancy.This paper focuses on elaborating new research progress on resveratrol's role in age-related eye diseases.

A proton nuclear magnetic resonance-based metabonomics study of metabolic profiling in immunoglobulin a nephropathy

OBJECTIVES: Immunoglobulin A nephropathy is the most common cause of chronic renal failure among primary glomerulonephritis patients. The ability to diagnose immunoglobulin A nephropathy remains poor. However, renal biopsy is an inconvenient, invasive, and painful examination, and no reliable biomarkers have been developed for use in routine patient evaluations. The aims of the present study were to identify immunoglobulin A nephropathy patients, to identify useful biomarkers of immunoglobulin A nephropathy and to establish a human immunoglobulin A nephropathy metabolic profile. METHODS: Serum samples were collected from immunoglobulin A nephropathy patients who were not using immunosuppressants. A pilot study was undertaken to determine disease-specific metabolite biomarker profiles in three groups: healthy controls (N = 23), low-risk patients in whom immunoglobulin A nephropathy was confirmed as grades I-II by renal biopsy (N = 23), and high-risk patients with nephropathies of grades IV-V (N = 12). Serum samples were analyzed using proton nuclear magnetic resonance spectroscopy and by applying multivariate pattern recognition analysis for disease classification. RESULTS: Compared with the healthy controls, both the low-risk and high-risk patients had higher levels of phenylalanine, myo-Inositol, lactate, L6 lipids ( = CH-CH2-CH = O), L5 lipids (-CH2-C = O), and L3 lipids (-CH2-CH2-C = O) as well as lower levels of β -glucose, α-glucose, valine, tyrosine, phosphocholine, lysine, isoleucine, glycerolphosphocholine, glycine, glutamine, glutamate, alanine, acetate, 3-hydroxybutyrate, and 1-methylhistidine. CONCLUSIONS: These metabolites investigated in this study may serve as potential biomarkers of immunoglobulin A nephropathy. Point scoring of pattern recognition analysis was able to distinguish immunoglobulin A nephropathy patients from healthy controls. However, there were no obvious differences between the low-risk and high-risk groups in our research. These results offer new, sensitive and specific, noninvasive approaches that may be of great benefit to immunoglobulin A nephropathy patients by enabling earlier diagnosis.

Characterization of Protein in Old Myocardial Infarction by FTIR Micro-spectroscopy / 华中科技大学学报（医学）（英德文版）

The aim of the present study was to assess whether Fourier transform infrared spectrometry (FTIR)micro-spectroscopy could produce distinct spectral information on protein of old myocardial infarction(OMI)and to set them as molecular markers to diagnose atypical OMI.Paraffin-embedded heart samples were derived from victims dying of OMI.In combination with histological stain,FTIR and infrared micro-spectroscopy,the characteristics of OMI were analyzed morphologicallyand molecularly.The most relevant bands identified were the amide A,B,Ⅰ and Ⅱ,showing crucial spectral differences between apparent normal region and OMI region,including the peak position blue shift and the increased intensity of OMI,moreover relative increase in a-helix and decrease in β-sheet of protein secondary structures in OMI.Comparing to single spectral band,the I1650/I1550 ratio was increased and rationally used as a molecular marker for diagnosing OMI.These novel preliminary findings supported further exploration of FTIR molecular profiling in clinical or forensic study,and were in accordance with histopathology.